Ingredient

Value

 Units

Description

Description

Organism

Target Type

Target Name

Target Organism

Reference

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

794.3

nM

PUBCHEM_BIOASSAY: MultiTox-Fluor Cytotoxicity Assay - LYMP1-001 - Live Cells. (Class of assay: confirmatory)

PubChem BioAssays

Homo sapiens

CELL-LINE

Lymphoblastoid cells

Homo sapiens

CHEMBL1201862

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

25.1

nM

PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory)

PubChem BioAssays

Homo sapiens

SINGLE PROTEIN

Endoplasmic reticulum-associated amyloid beta-peptide-binding protein

Homo sapiens

CHEMBL1201862

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

39810.7

nM

PUBCHEM_BIOASSAY: MultiTox-Fluor Cytotoxicity Assay - LYMP1-003 - Dead Cells. (Class of assay: confirmatory)

PubChem BioAssays

UNCHECKED

Unchecked

CHEMBL1201862

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

47307.9

nM

PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory)

PubChem BioAssays

Homo sapiens

SINGLE PROTEIN

Nuclear factor erythroid 2-related factor 2

Homo sapiens

CHEMBL1201862

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

79432.8

nM

PUBCHEM_BIOASSAY: Cell Viability - LYMP2-010. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory)

PubChem BioAssays

Homo sapiens

CELL-LINE

Lymphoblastoid cells

Homo sapiens

CHEMBL1201862

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

11220.2

nM

PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)

PubChem BioAssays

Mus musculus

SINGLE PROTEIN

Nuclear receptor  

ROR-gamma

Mus musculus

CHEMBL1201862

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

446.7

nM

PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]

PubChem BioAssays

Homo sapiens

SINGLE PROTEIN

Aldehyde dehydrogenase 1A1

Homo sapiens

CHEMBL1201862

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

12589.3

nM

PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory)

PubChem BioAssays

Homo sapiens

SINGLE PROTEIN

Endoplasmic reticulum-associated amyloid beta-peptide-binding protein

Homo sapiens

CHEMBL1201862

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

31622.8

nM

PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ]

PubChem BioAssays

Homo sapiens

SINGLE PROTEIN

Cytochrome P450 3A4

Homo sapiens

CHEMBL1201862

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

10000

nM

PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))]

PubChem BioAssays

Homo sapiens

SINGLE PROTEIN

15-hydroxyprostaglandin dehydrogenase  

[NAD+]

Homo sapiens

CHEMBL1201862

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

79432.8

nM

PUBCHEM_BIOASSAY: Cell Viability - LYMP2-013. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory)

PubChem BioAssays

Homo sapiens

CELL-LINE

Lymphoblastoid cells

Homo sapiens

CHEMBL1201862

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

74978

nM

PubChem BioAssay. qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway - cell viability counter screen. (Class of assay: confirmatory)

PubChem BioAssays

UNCHECKED

Unchecked

CHEMBL1201862

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

50118.7

nM

PUBCHEM_BIOASSAY: Cell Viability - LYMP2-024. Luminescent cell viability assay, measuring the amount of cellular ATP in the cell line following compound treatment for 24 hours (Class of assay: confirmatory)

PubChem BioAssays

Homo sapiens

CELL-LINE

Lymphoblastoid cells

Homo sapiens

CHEMBL1201862

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

125.9

nM

PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory)

PubChem BioAssays

SINGLE PROTEIN

Thyroid hormone receptor beta-1

Homo sapiens

CHEMBL1201862

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

CC50

200000

nM

CC50 reflects the drug concentration that elicits 50% cell death of CEM-SS cells and HIV-1RF was measured using XTT assay.

Scientific Literature

Human immunodeficiency virus 1

ORGANISM

Human immunodeficiency virus 1

Human immunodeficiency virus 1

J. Med. Chem., (1998) 41:9:1371

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

TI50

5.3

Therapeutic index (EC50 / CC50) was evaluated

Scientific Literature

UNCHECKED

Unchecked

J. Med. Chem., (1998) 41:9:1371

https://www.ebi.ac.uk/chembl/compound/displayimage/40828

CHEMBL28517

Potency

31622.8

nM

PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ]

PubChem BioAssays

Homo sapiens

SINGLE PROTEIN

Cytochrome P450 3A4

Homo sapiens

CHEMBL1201862

 

 
 
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